real world in what.
For a home user who usually just plays games, and using it as an OS and Apps drive. no noticeable difference. people cry out on the video comparisons of SSD vs HDD saying they are not fair or apples v apples;
so they then redo the videos with the fastest 10k hdds versus 1st gen SSD and you pretty much see the same results in the real-life home user tasks.
If you were using it as a piece in their of a complex data serving solution, then maybe yes you'd notice difference and have to tune specifically for each drive.