Depends on your two 450W units, the 4870x2 will pull about 280W, but 75 of that comes from the 24 pin main connected connected to the motherboard so the primary PSU will will be under reasonably heavy load and if they are low end units a single one might not have enough juice to even power a 4870x2 alone even with the other one handling the rest of the system.
If you buy yourself a good quality 650W unit it will be plenty to power the 4870x2 and you dont have to deal with combining units.