It will work with your motherboard. The questions that remain are these:
What CPU do you have?
How much RAM?
What kind of Power Supply Unit do you have? (PSU)
-- What are the max continuous Watts ratings on your PSU?
-- How many amps are rated on the 12V rail on your PSU?
What kind of case do you have? (i.e. will the video card fit in your case)?
Depending on all these answers, folks can tell you if it's worth upgrading (i.e. will your system keep up with it). Plus we can determine if your PSU will handle it, and whether it will actually fit in the case.
If your PC was purchased in a box, with a specific model number on it, we can look it up with Google. If not, or if it's been customized, you'll need to open the case and look at the label on it (or even take a photo!).