I have an ACER 53xx aspire desktop with Q6600 where the I/O get totally disabled, and I am unable to wake the computer up. Somtimes it happens while working.
I would have to restart using the on/off switch.
I tried to change the Sleep mode, keep the computer up all times, and other normal parameters. nothing is working. I am suspecting some type of an overheat or a fault that is not reported. Note I am not getting any alarm on overheating but my suspision is on a part that is critical but not reported.