[Solved] Catalyst control centre 10.4 not saving settings after reboot

That would be possible.
Did changing the PSU help you ?

Update:
I installed the card on another system:
E8400, DFI Lanparty DK-P45 Plus, 2X2GB DDR2 800mhz,FSP- Blue StormII 500watt, ATI 4870 (removed along with its driver -9.7 by driver sweeper), win7 RC x64.
I restarted few times with no problem, then I installed my PSU in this system and I'm testing it now...I'll keep testing then tell you the results, but so far it appears as software problem in my system, but I'm not fully sure yet..What software conflict a fresh windows installation can't fix?!!

I'm starting to pull out my hair!! I used a 4870 in my system and it ran just fine, then I re-installed the 5870 into my system with another PSU, restarted a couple of times and the problem appeared again!!!!!!!!!!
So to put it straight:
1--My GFX (5870)+My mobo (ASUS P5KSE)+My ram+Both PSUs (mine & my niece's)=the issue appears
2--My GFX+My mobo+ Another RAM+My PSU=Not yet tested!
3--Another GFX (4870)+My Mobo+My RAM+My PSU=No issue
4--My 5870+another mobo (DFI P45)+Both PSUs + Both RAMs=no issue

So it seems the issue only appears when I have both my 5870 and ASUS P5KSE in the system! I'm starting to believe it's a PCI-e 1 problem, what do you think guys?

hmm,you did quite lot of efforts,the only last thing i can think of is to update your P5K's BIOS and test again with your 5870.
let us know how it goes
Also calm down mate your case is one of the strangest problems i have ever seen,so we need time to think and then we can guide you

@ Maziar:
Thanks bro, and sorry for losing my patience but this issue is driving me crazy!! I have only one month warranty (yeah that's the case in my country) and I don't expect my P6X58D mobo to get here while it lasts, so my biggest fear is that this stupid issue appears in the new system and by then I can't return the card!
I did update the mobo's bios to the latest (1404) version a week ago..I also removed the monitor driver (which was dlled from windows update), with no result!..Now I'm thinking of 2 things:
1- Removing CCC10.4 and reverting to 9.12
2- Updating the VGA bios..Can any body tell me where to get the latest version ? Force3D site does not provide it.
Can you think of any other thing to do?

Try 10.4a too and if it didn't help,revert back to an older driver

Thanks everyone..
@ Zipzoomflyhigh: I didn't try vista..I may try it later but I'm trying to avoid the pain of backing up my saved games, installing windows, and re-installing ~ 100 GB of games again!! But I think I need to try that sooner or later, so can you or anyone else give me a link to dll DX11 for vista?

@Maziar:
Is 10.4a a beta driver? Is it newer than the 10.4? I'll search for it and try it.

@Uber:
Of course I installed the correct 64bit drives, but not under safe mode, can you explain to me how's safe mode gonna help? Thanks... I did use driver sweeper under safe mode to get rid of all the 'junk', but as I said before, even a fresh windows installation didn't help!

@Maziar
The 10.4a didn't help :s
@zipzoomflyhigh:
The issue happened with 10.3 and 10.4. And I'm not sure the problem won't manifest in vista. There is only one way to know for sure

I forgot to mention that the issue only appears when I shut down the PC..If I restart after correcting the desktop (by rotation-canceling mentioned above) then everything is OK...I tend to think of it this way: as long as the card holds power then everything is alright, ccc remembers settings and the desktop is shown correctly..Once the card loses power (in shutting down) then it'll revert every setting to the default and shows only part of the desktop. Any input on that?

First,install 10.4 or 10.4a again and raise your 2D clocks,here is how:
1_Open CCC and choose Overdrive tab,unlock the settings(by clicking on the " Gold Key" icon)
2_Go top options,profile and choose profile manager.
3_In the composition tab,choose "The following settings" and in the "ATI Radeon HD 5900 series"make sure only ATI overdrive is checked.
Then enter a profile name,then save and close it(Do not activate).
4_Go to C:\Users\Your UserName\AppData\Local\ATI\ACE\Profiles (Its hidden so make sure you unlock hidden files and folders)
5_Open the profile with wordpad and do this edits:
<Feature name="CoreClockTarget_0">
<Property name="Want_0" value="40000" /> (default is 15700)

<Feature name="MemoryClockTarget_0">
<Property name="Want_0" value="90000" /> (default is 30000)

Save the changes and close.

6_Open CCC,in options tab go to profiles,profile manager and choose the profile that you saved before and then click on Activate and close.

Thanks zip for your kind reply, I did try that about 10 days ago, and my mobo's bios now is the latest (1404).
I'm hoping that the issue won't appear on the P6X58D premium I'm expecting. I don't know if it's a software conflict but I tried a fresh installation of vista with only ccc 10.4a and the issue appeared soon after shutting down and starting windows again. And if it's software-related then why the card sticks to 2D clocks when the partial desktop issue appears?
If only I can get an updated VGA bios..

Best answer selected by avatar_raq.

Update:
The ASUS bios I used (linked above) produced another issue. When I connect another display to the other DVI or the HDMI port, CCC recognizes it but the display reads 'no signal detected'..I tried different monitors and cables, different CCC settings with no use. I then reverted back to the original bios which I backed-up and the monitors worked fine, but the original issue re-appeared ! After some trial and error I settled for this bios:

http://www.techpowerup.com/vgabios [...] 91112.html

Although I lost the improved fan profile and the extended CCC overdrive limit of the ASUS bios, both issues seem to vanish with this one. So I'm keeping it one for now..I'll keep you guys updated.

Everything seems to run fine now