Could my motherboard not be reading mice correctly?

My mice all seem to be having problems when I connect to the computer I am using. I doubt all 3 could all have problems as they are relatively new. Could it be that my motherboard doesnt properly interpret them? Kind of a noob with computer so may be a dumb question. Any help is appreciated

Edit:Should be moved to gigabyte.
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  1. Moved that for ya :)


    What interface do the mice use?

    If PS/2, that port on the mainboard could be defective.
    If USB, try a different set of ports on the back of the mainboard.
  2. They are all USB, changing has no effect :(
  3. if know the model .. u may check the latest bios for update first ...
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