1) If your motherboard is a server based board, I would run ECC memory. I would make sure it is been tested by the manufacturer or on the QVL certified for the board. You want to look for all items that have been tested or certified to prevent potential issues.
2) Certified memory should run with nothing or only minor changes in the BIOS. I would review the manual for how to adjust your DRAM FREQUENCY, Speed (MHz) & Latency.
3) ECC stands for Error Checking & Correcting of the memory. It is a feature where the RAM checks itself for errors & corrects. It is widely used on servers to increase the stability of the system. Standard PC's use non-ECC since there is no real benefit on those types of systems.