Be careful then! Unless you really smack it hard you're not gonna break anything.
Some domestic vacuum cleaners can create static though, which will be very, very bad to them electronics. You can get anti-static vacuum cleaners though, which are a godsend.
You can also make a grounding line that slips over the nozzle, (See my last link :P)
Plus the nozzle is very rarely closer than 6'' to a component, I loosen any fluff with a non-conductive 'pokey-stick' Tm :P
Fans are prevented from turning using clips and I also use anti-static brushes