Your best bet is to look at the motherboards you are interested in for memory limits.
You need UEFI bios (Probably hard to find for Q57) and a 64-bit operating system, if you want to boot a 3 TB.
Otherwise you can use the 3 TB disk for data for systems after XP.
For XP 3 TB drives you need GPT loader software (Paragon for example).

http://www.hitachigst.com/tech/techlib.nsf/techdocs/869E4925CC72E233862577E100235119/$file/Deskstar_3TB_FAQ_finalwebv2.pdf

http://ark.intel.com/chipset.aspx?familyID=41724

http://www.intel.com/Products/Desktop/Chipsets/Q57/Q57-overview.htm