I would go with 2 modules as opposed to 4, for 2 reasons.
1.) If you have a motherboard with 4 slots and you use them all, lets say 4x2GB for a total of 8GB, then if you want to upgrade to 16GB in the future you will have to buy a 16GB kit (4x4GB) as opposed to only having to buy another 8GB kit (2x4GB).
2.) In my experience using all 4 slots increases your chance of encountering problems. Always best to use 2 slots as opposed to 4.