Usb ports & ps/2 not working


I have a HP Slimline Desktop that runs on Windows Vista. And recently I tried to start the computer and it wont start up or wont go past the opening HP screen. Also the Keyboard (ps/2) doesn't work, nor does anything that is plugged into the USB ports. What should I do?
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More about ports working
  1. "wont go past the opening HP screen" you can't even post or get into the BIOS? Any beep codes when first turning on? Possibly the MB has started to flake out... Or the memory has gone bad... ??
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