The PCI-E x16 slot will take PCI-E 2.0 x16 cards its backwards compatible. There are some exceptions so its a good idea to just check with the company who make your Motherboard. Most websites will have a link to compatible graphics cards. There is also the possibility that you may need a Bios update for compatibility.
Generally the compatibility is pretty good and im mentioning it so you are fully informed. Wouldn't want you buying something that didn't work would we.