Why wouldn't it - your computer (assuming you meet all requirements: power supply sli bridge mb that supports 2 or more gfx), more importantly - nvidia control panel - you will need to go there and configure which to do what you want them to do.
To answer your question: Yes, it would.
GTX295 as a primary card and GTX460 as physX card are wasting money...
A single GTX295 is already FAST ENOUGH to run anything without PhysX card...
I am still going to need a 3-d capable card.I am waiting for the 27 in Asus 3-d models to come out. I wonder if 3-d still will be able to be utilized if I get a GTX # 460 and use for physix.In the general scheme of things,I wanna sell the #295 and get another #460,but for now I wanna see what options I have with these 2 specific cards(#295&460)