HELP! memory config for ASUS RAMPAGE III EXTREME mobo

Hello,
Purchasing a
ASUS Rampage III Extreme ATX LGA1366 X58 DDR3 4PCI-E16 PCI-E4 CrossFire SLI SATA3 USB3.0 Motherboard

CPU: Intel i7 Extreme 990x 3.4GHz

Accepted Memory configuration setup on mobo:
6 x DIMM, Max. 24GB, DDR3 2200(O.C.)/2133(O.C.)/2000(O.C.)/1800(O.C.)/1600/1333/1066 Hz Non-ECC, Un-buffered Memory
Triple Channel Memory Architecture
Supports Intel® Extreme Memory Profile (XMP)
* Hyper DIMM support is subject to the physical characteristics of individual CPUs.

My question(s) is what does the numbers in front of "O.C" mean and how do they translate into performance?
Also, would you recommend going with 4gb or 6gb sticks for performance?
Recommend manufacturer as well please!

Thank you in advance! :sol:
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