If the q8300 is on the "cpu support" list on msi's website and the bios program is the same as your current bios, then you shouldn't have to do anything. If you're not overclocking, I don't recommend cleaning the cpu; if you want to add any thermal paste, place a single drop on the center, and let the pressure from the heatsink spread it out. Handle the components as little as possible. If temps change slightly, don't get too paranoid about it. Some folks worry too much about temps.