Mixed DD3 RAM? I mean, it will run at the speed of the lowest part installed...I'd recommend matched parts. I run 12 GB in my desktop in a similar configuration just fine. That said, 12GB doesn't offer much benefit in daily computing over 8GB...but I do a lot of VM work, so I love having 4GB to assign to a Vista VM, 2GB to assign to each of 2 Ubuntu VMs, etc.