It depends. Will you be running more than 1 graphics cards? Do you have any special requirments?
If you are looking for overall solid motherboard for everyday use and even overclocking, I would suggest:
Asus P8Z68-V (GEN3) (GEN3 was just released, coming in stores this month)
Asrock Z68 Extreme3 Gen3
If i run SLI GTX 460's, should i get P8Z68-V PRO? or P8P67 PRO?