It might be tricky, as the 680i is a big pita sometimes. Try it! Just leave the multi alone, set the FSB to 1333 and see if it posts. If it does POST (which it probably won't) check the temps ASAP. If they're safe, stress it and with a good bit of luck, it won't BSOD or kick back errors. Just watch the temps, as I assume you're using stock cooling.
I really wouldn't recommend the set it and forget it steps to an OC, but quite a few people can get to 333x9 easily without changing anything else. If you get there and want to go higher, you'll have to be a bit more methodical about vcore and FSB.