Nope this board is designed for a single graphics card. Does not support SLI or Crossfire. It does not have any additional PCI-E x16 slots for another card so it is physicly impossible for high end graphics cards. If you doing it for muliple monitors beyond 2 then you can get a super low performance pci slot card and add that in. But this will not incress game performance. It's not like SLI. It's just to give you extra monitor support. is that what your looking for?