Probably but not very well.
Saints Row 2 isn't a GTA killer, but it's a GTA alternative. It's tough not to hate on the slightly lacking production values, but when you see the rest of the game it actually makes a bit more sense. The technical shortcomings are the only truly bad part of Saints Row 2, and, sadly for PC gamers, it pretty much kills their experience unless they can play with the bulk of the visual settings turned down or off. Not doing so ruins your gameplay experience. There's enough crazy-insane tomfoolery to keep a machete in the hands of even the most straight-laced citizens, you'll just need a super-computer to even think about running it.