Is it possible to run two of these in SLI? I'm under the impression the the card takes up two slots, and therefor I can't. If I can't run two of them, how would I run Dual GTX 480s without overheating issues? I don't know how to install cooling systems.
Yes it is possible! Each card occupies 1 slot and blocks another(PCIe x16 slots are usually not right up against each other other slots in between). In a well ventilated case there should not be any overheating issues.