The greater pixel count will lead to lesser fps. So the 3 monitors with 6,220,800 pixels vs. the 1 monitor with 4,096,000, the extra 2 Mil pixels (50% more) will run slower.
That's why I'm a fan of the three 5:4 monitors yielding 3.9M pixels (same as the 30" monitor) but gives a wider viewport and has move utility (3 separate screens). You can drive it with a single 5850 even. (Currently running 5850s in XFire with it). However, the 16:9 movies in games bleed into the adjacent screens (lazy developers...) so until this is handled correctly, it's definitely a minus to this setup.