You only have 1 PCI-E x16 slot so you would have to cut one of your PCI x1 slots with a dremel tool or melt it with a hot iron to fit an x16 card in your x1 slot (there are no x1 cards or PCI cards worth running for PhysX). Apparently the bandwidth isn't much of an issue so yes you CAN, but I wouldn't. Too much hassle and expense for not enough benifit IMO.