The ModX would probably handle it but depends on the rest of your setup, OC etc.

You would also need to use 2 pci-e adapters as the ModX only comes with 2 and you will need 2 for each card.

I ran 2 GTX460's on my ModX700w and that was fine, until it blew up. :D

Ideally I'd be looking at a decent 650w+ unit with 4xpci-e cables, any of these would do ya.
http://www.newegg.com/Product/Productcompare.aspx?Submit=ENE&N=100007657&IsNodeId=1&srchInDesc=650w&page=2&bop=And&ActiveSearchResult=True&CompareItemList=58%7C17-207-007%5E17-207-007-TS%2C17-139-012%5E17-139-012-TS%2C17-151-088%5E17-151-088-TS

Personally I'd go with the Corsair unless money is no object then the Silverstone.
 

Nivea

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Apr 20, 2011
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The rest of the system is probably going to be a Phenom II 955-975, 8GB Ram, 3 HDD's for now, sound card, network card, case fans etc. The two 5850's would be for the future I'm getting one for now, I'm getting a Cooler Master Elite 460w PSU for another system, but I was going to get the antec 650w PSU if I needed it for the future two 5850's and migrate my Zalman PSU (another system's PSU) over and migrate my OCZ 600W PSU over to that system, thanks for the replies.