For those that dismiss the "cache" scenario out of hand, i.e. could buy a 2TB HDD and a stand alone SSD, they miss the whole point. Caching takes the "work" out of deciding the data that you want in the SSD. The more you use the app/data, the more likely most of it will be in cache, and you only have to work with a single drive letter.
The other scenario that You could use from OCZ, is do what I've done. Use their synapse drive as the cache, with a 5 *1TB RAID 1+0 on an Gigabyte X58 Mboard, i.e. no Z68 option available.
So I get the security/speed of a RAID array, and quick load times for OS and my favourite games, when cached. (The synapse is via the SATA III channel.)
For the ultimate, scenario, just add another 60GB SSD for those choice games/apps for those that absolutely positively had to be loaded ASAP.
Simples.