Yes, just plug into first Sata II slot. Will lose some performance. Primarily on the Sequencial read/writes. But this is the LEAST important parameter for an OS +Program drive.
For installation of Windows (recommend a freash Install), first disconnect all HDD, reconnect after the Windows installation is complete
Don't forget to verify/set AHCI mode in BIOS.
When installation is complete, down load and install Intels RST driver (Newest is 10.8 I believe.
Down load AS SSD - don't need to run Bench marks unless you want to. But Look at upper left, it will:
Identify SSD and latest firmware
Should show driver = msahci, after update driver to Intel then should read iaSTor.
Will show that partion alignment is correct.
Most of the 'issues' in the feedback and with most SSD's is because folks fail to match-up BIOS = AHCI <=> Start = 0 and instead Windows is improperly set to Start = 3 = IDE and the wrong drivers are loaded.
Use 'Fix It' or correctly set the registry values; see -> http://support.microsoft.com/kb/922976