I am kinda torn between a 1366 build and a 1155 build (latter one come April when boards are re-released .... the CPU's are still here but the MoBo's have been recalled due to a chipset defect affecting 2 of the 6 SATA ports .... new parts shipping now, expected in channel in about 6 weeks).
In the 1366 build I'd used a Quadro rendering GFX board. But , for the most part, I think you'd be best served by a a Sandy Bridge build. 'm going to try and spend ya whole $2500 budget, cut out whatever you think is extravagant
Case - $180 - Antec P193
http://www.newegg.com/Product/Product.aspx?Item=N82E16811129062
Case Fans - $15 - Antec Red 120 mm
http://www.newegg.com/Product/Product.aspx?Item=N82E16835209013
PSU - $120 - Antec CP-850
http://www.newegg.com/Product/Product.aspx?Item=N82E16817371024
MoBo - $390 - ASUS P8P67 Pro
http://www.newegg.com/Product/ComboDealDetails.aspx?ItemList=Combo.575884
CPU - incl above - Intel Core i5-2500K
http://www.newegg.com/Product/Product.aspx?Item=N82E16819115070
Cooler - $80 - Antec Kuhler 620
http://store.antec.com/Product/cooling-cpu_cooler/kuhler-h2o-620/0-761345-77085-9.aspx
RAM - $155 - (2 x 4GB) Mushkin CAS 7
http://www.newegg.com/Product/Product.aspx?Item=N82E16820226178
RAM - $155 - Same
GFX - $370 - EVGA GTX 570 SC
http://www.newegg.com/Product/Product.aspx?Item=N82E16814130549
GFX - $370 - Same
HD - $65 - Spinpoint F3
http://www.newegg.com/Product/Product.aspx?Item=N82E16822152185
HD - $65 - Same
SSD - $245 - Crucual C300 2.5" 128GB
http://www.newegg.com/Product/Product.aspx?Item=N82E16820148348
Card Reader $35 AFT XM-35U
http://www.newegg.com/Product/Product.aspx?Item=N82E16820176016
DVD Writer - $120 - ASUS BR Model BW-12B1LT
http://www.newegg.com/Product/Product.aspx?Item=N82E16827135234
OS - $140 - Win 7-64 Pro OEM
http://www.newegg.com/Product/Product.aspx?Item=N82E16832116758
That's $2,510 .... told ya I was gonna try and spend all ya money
Things you might wanna change:
1. I made the assumption of it being a "work machine" so went with the "understated look". If ya want something more snazzy, the Antec DF-85 could be substituted at $20 less. Another would be the HAF-X but w/ a non Antec case, ya wouldn't fit the CPX form factor CPU in, so I'd go with another 10.0 rated unit and put in a XFX Black EDition 850 .
2. Another $100 will get ya a 2600k
3. The self contained water cooler avoids any heat sink interference issues between the air cooler and the RAM modules. A scythe SCMG 2100 w/ Shin Etsu TIM would cost just $45 if ya went air.
4. For what you're planning low CAS RAM is recommended ..... doubt ya need 2 sets but since cash was there, I went w/ 16 GB ..... might wanna try it w/ 8 and add later if ya think ya need.
5. GFX - Same deal ..... you don't need the 2nd card but the case and PSU are sized to handle it. For occasional gaming, you'll be more than happy w/one 570.
6. HD's - Another "same deal". If ya don't need two hard drives in RAIF 0 or RAID 1, don't bother.
7. SSD - Since waiting till April I'd wait for the 3rd generation Sandforce units.
8. Card Reader - For importing graphics .... also note that if ya go with the DF-85 it has an external 2.5" hot swappable drive bay which is very cool and convenient for just that purpose.
9. Need Blue Ray ? If not spend $22 for a DVD Writer ...again,m budget was there so included the otpion
The above deducts would cut ya down to about $1800.