I know I need to have the front for intake, rear for exhaust, so those two are set. Should I set the two side fans to intake and the two top ones to exhaust? Or the bottom side one to intake, top side one to exhaust; and one intake, one exhaust on the top as well? Which method would provide the greatest airflow/cooling ability?
Sides intake, top exhaust. Although side fans can cause disruption, or turbulence, with the air flow. If you have heat issues with graphics cards, unplug or slow down the side fans to see if temps improve. Just keep in mind a steady stream of air vs. just a high volume.