Set everything 1000/full.
Jumbo Frames has had a lot of concerns in how it operates. Last I knew it was recommended to not turn this on unless all your traffic was local. This has shown in the past to cause issues when going out the WAN. The router is stuck dicing up the frames and it will cause a slow down.
But turn it on and do your own testing and see what works for you. For testing at the WAN level you can do a ping test and set your packet size to see at what point your router is hacking the packet up.