The cards have to be the same, e.g., same interface type, model, vram size, and speed! If one card is OC'd and one is not, the OC card will underclock to the other card's speed (I think, I'm pretty certain this is true).
PCIE 2.0 cards are backwards compatible.
So it should work, they just have to be the same gpu, if one has less/ diff. ram/speed than the other the sli system uses the lower value for both.