well i installed the newest drivers 260.99 and set my resolution to 1024x768 which worked fine on the 8600gts but with the 460 gtx the folders and fonts looked weird,it worked with 1284x1204 i believe it was. but at the highest resloution the folders looked too small,i cant work with that:P
This sort of problem is not due to the card itself. It's a driver issue that all the Nvidia cards will have and likely will be an issue with the new card you will buy.
There are ways to increase the folder size within windows and will work with any new card.