That's what I do and have done for years, and to make things seamless I change the Default locations for the Documents, Music, Photos, etc to a separate HDD; in my case I really like SSD + RAID 1 HDD with back-ups on an external HDD, NAS or Windows Home Server.
SSD (OS + Apps + Working Data) and HDD (Data + Storage).
/edit - when installing the OS, do it right and read this -> http://www.tomshardware.com/forum/303873-30-wont-resume-sleep-booted-raid#t2068879