Most MB's on the market today run the ram channels through the CPU's, which can only run @ 1.5V and @1333 So when the bios receives info that there is a spd/Voltage of higher specs it believes that you/somebody is trying to overclock and attempts to compensate. This usually ends in an instability. To over come this, it takes some major moxy know-how and manipulation in the bios and sometimes even windows itself to get everything up and running stable. Even then, you may have to reset everything in the bios each time you restart.
For some this is fun and a constant exhilarating challenge. For others it's a major pain in the B. It depends on your point of view.
JM