wolfram23 wrote :
Honestly an AMD Radeon 6970 2gb card will run all 3 monitors and game one just 1 monitor fine. As mentioned if you go with Nvidia even just to run 3 monitors and game on a single monitor you'll still need to go with 2 cards. I would probably say SLI 560 Ti 2gb versions (from Palit) if you go that way, but a single 6970 2gb is going to work on its own and puts out good FPS at 2560x1600.
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Check THESE benches out. You're going to be running into trouble gaming at 2560x1600 with a single card unless it's a 6990 or a 590.
If you really aren't concerned with gaming on all 3, my recommendation would be CF 6950's. I have been considering similar options for my own setup (3 1280x1024 monitors, very close to the same total pixels as 1 2560x1600), and it looks like the 6950's offer the best combination of price and performance. Once you hit 2560x1600, the 1GB 560's run into a vRAM bottleneck, and although Palit DOES make a 2GB version, I'm not really a fan of their cards. I forgot to bookmark the article I found about this, but I'll keep looking for it. The main point it made is that the 6950's DOMINATE at 2560x1600. Here's another set of benchmarks for you to look at that show what I'm talking about.
I actually used to use a solution similar to what geofelt was talking about (I had a PCI 9400GT driving my peripheral monitors), and it DOES work pretty well. However, with the horsepower of the CF 6950's, you will definitely have enough spare to drive the peripherals.
If none of the monitors have a DisplayPort output, you'll need to grab an active DP to Dual Link DVI adapter, but I'm pretty sure they're relatively cheap nowadays.
If you feel like splurging and getting SLI 580's, by all means do, but the 6950's should be more than enough.
EDIT: Somehow I completely missed the fact that you already have a 4870 x2. Picking up a second one should be enough to game on a single 2560x1600, and you can always pick up a cheap card to drive the two other monitors. That would definitely be cheaper than getting the CF 6950's. Just consider that you ARE buying cards that are now 2 generations old, and you can always sell your old card to cover part of it. I would say do whatever your budget allows, so if you can afford the 6950's (or even the 580's), do it.