silky salamandr said:
You mobo HAS to support the bus speed of the chip. If your chip is faster than your fsb on your mobo it WONT work. You cant run a 1333 chip in a 1066 fsb mobo. If you look at the link that DX provided, it says nothing about supporting a Core 2 Quad.
Generally true although some motherboards will overclock. For example my Gigabyte P965 DS3 v2 supports FSB up to 1066 however the E8500 IS on the official supported CPU list at 1333 FSB with a note that the latest BIOS is required as is overclocking.
I guess it may be hit or miss as to whether you can actually make an overclock stick so not worth the risk but it is technically possible.