Some points:
1) I noticed a big difference when temporarily downgrading to my Velociraptor 10K drive from an OCZ Vertex 3. Start times and program opening times were slower. I was quite surprised at the overall difference. So a good SSD will make a big difference.
2) 60GB was too small after Windows applies Updates, System backups etc. I recommend 120GB.
3) The best deal I saw was the 120GB OCZ Agility 3, at NCIX on sale.
4) Even if someone only had SATA2 and not SATA3 on the motherboard, I would still recommend the newer SSD's like the Vertex 3 or Agility 3 from OCZ. Most of the file transfers involve smaller files which transfer slower than the 300MB/second cap of SATA2. I even compared a Vertex 2 to a Vertex 3 when installed in a laptop that had only SATA1 (max 150MB/second). The Vertex 3 was STILL noticeably faster!
5) I have my system setup like this:
Drive 1:
120GB OCZ Vertex 3 (Windows 7 and programs)
Drive 2:
2TB hard drive (*Games, backup images, downloads and Multimedia files)
*You'll have to choose the manual method when installing games. I first created the folder "GAMES" on my 2TB drive, then I install games to that.
I also added the folder "STEAM" on my 2TB drive which I setup Steam to use. That's all automatic once it's setup.