I have a Microsoft blue laser wireless Mouse 5000, actually I have 2 LOL, and have confirmed that you can indeed disable the right mouse button. This is not a notebook mouse. My hands aren't large but I am not petite and I dont care for those tiny mice either. If you try one of these , I got my most recent one for $20 at staples (they are 39 regular price there), be sure to disable scroll wheel acceleration. It drives me whacky and I think it would you too.
edit - ps - my wife is waiting for them to go on sale again too. I also forgot to mention the blue laser will track on just about any surface; the arm of the couch, the deep pile rug on my floor, the dinning room table... Its awesomer (as my kids would say)