No you need to uninstall the drivers if you want everrything to work correctly.
Download latest drivers from Nvidia for your operating system.
Download driver sweeper from Guru 3dhttp://downloads.guru3d.com/Guru3D---Driver-Sweeper-(Setup)_d1655.html
Install Driver Sweeper
Go to controll panel and uninstall Nvidia display driver.
Reboot into safe mode and run driversweeper . Delete all left over Nvidia display driver fragments.
Shut down. Now remove old card and install new one.
Make sure to attach PCI-E power cable to card.
Boot computer and install the drivers you downloaded. Not the ones on the cd that came with the card.
Enjoy your new card.