What video cards are you working with? And what are the statistics on your power supply?
Video cards that aren't gaming or producing detailed objects, are operating at idle power. Often this is a very low wattage. So disabling the second video card to conserve electricity isn't going to make a big difference. Often at idle, video cards don't take more than 20W of power.
When working with two video cards you do get an increase in performance, along with an increase in heat generated. Before adding a second video card, consider the strength of your power supply. Does it provide enough Wattage and AMPS? These AMPS are located on the 12 volt rail.
Also, does your power supply carry the appropriate connectors? For example, some cards require one or two power connectors. Sometimes, when dealing with high end video cards, they might have one 6-pin and one 8-pin. If your power supply has these appropriate connectors for the video cards you are thinking of, then you are in good shape.
Another point to consider (I hope I'm not making this too dull), does your motherboard support SLI (probably)?
So, to sum it all up, If you have good cooling, plenty of power, and a motherboard that supports SLI with a good bandwidth, then yes I'd say go for it.