You are right about the CUDA aspects, they may produce a performance boost (over the AMD alternative) to Adobe graphics programs. With Virtu on the Z68 you will be able to use both the iGPU and descrete GPU. The cooling depends on the model and brand of GPU that you choose. Stick with the reference models (non-OC'd) because you can OC on your own with MSI Afterburner software (yes it works on other brands of cards). And if Afterburner doesn't work there are other programs to OC GPUs.