Long story: Depends on the clearance of your case for the card, but yes, can replace the power supply with ease. I can't find anything that says your case size, so measure the distance (at the level of the PCI slot) from the back of the case to the back of your Hard Drive rack(s) or whatever else may be level with your PCI slot, and let us know. That will help with the size of the card you can install.