The above reply is certainly an option.
What you're asking about though is certainly possible and is a popular solution.
I use this on both my desktop and laptop. 120GB SSD for Windows, startup programs and a few of my most used applications, with HDD for the rest of my programs and personal files such as documents, pictures and videos.
It's simple to do and every effective. There are just two things to remember. Firstly, when you install a program, you need to change the drive letter of the installation path. It will normally default to C but you need to change it to install on the other disk if you want it to.
The second thing is to change the location of your library folders (Documents, Movies, Pictures etc) to your HDD. This is a relatively simple procedure, one time only and several websites give instructions on how to do it.