So over the years Multi-GPU support has improved quite a bit, AMD still isn't up-to snuff at the level of NVIDIA though, multi-GPU supports still literally and directly remains the Achilles heel of ATI's Catalyst drivers.
So let's round things up, personally we always say stick to one or maybe two high-end cards as there is so much less driver fuzz to worry about. It's like this with ATI, once you pass 2 GPUs you'll often find yourself compromising a lot with new game titles versus multi-GPU support. And this is why today's tested products in 2-way CrossfireX mode work so well.
AMD really does needs to step it up a little more on better and even faster game profile support AND user based and created profiles, period......