Yes, the mobo and hdd lock with the OS. if you change one, you need to reinstall. also, do you have proper thermal paste applied and the heatsink/cpu seated correctly? what psu did you buy? make and model, watts, and amps.
the brand and model are good, but it doesnt mean that they dont go bad. use a power supply tester, and make sure. That is my best guess though with what you have said. i own HXxxxx from Corsair too, they are great units. every unit though can go bad, no matter what.