I haven't purchased parts yet, but I'm curious if this is possible. My future rig will run on a Sabertooth X79, I'll be running Radeon HD 7870s in crossfire. Can I still use the third PCIe slot for something non graphical? In this case I'm talking about a wireless nic.
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Yes you can. The X79 system was designed with a huge amount of PCIe lanes for exactly such a purpose.