Hello, Will this work in a Lenovo Y-480 Laptop,HyperX Plug n Play 16GB (2x8GB) Kit of 2 1600MHz PC3-12800 DDR3 Non-ECC CL9 SODIMM Notebook Memory KHX16S9P1K2/16 - I get some yes and some no, I know your one of those who knows what they are talking about after 20 years on your site.
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I don't see why it wouldn't work. So I have to say yes, it will work.
So the CL9 should not be a problem with this Laptop Lenovo Y-480.
Nope, I don't see how RAM timing can make it incompatible with your laptop in this case.