Well ya got 4 fans to start with and big ones if I remember right ( 200 's or 230 's ?). I dont own one but I think ya can get at least a 240 rad on top if your going with a water loop . Or a rea mounted h80 perhaps . I agree with ko888 in that a loop for the gpu would be good . Diminnishing returns sinking money in to water cooling the cpu . On the other hand the heatsink cpu coolers ala Noctua and what not are the size of a small car, But what ever you do , at least ya got a big airy case to start with . Best of luck