Yes you should be able to Crossfire those two cards. I would put the wider card (since it has more output choices) in the first slot (The long slot closest to the CPU). The other card goes in the other x16 slot (see your motherboard manual if you're not sure which one). Make sure you link up the two cards with a crossfire bridge. Hook your monitor(s) to the card in the first slot. Then boot-up and go to Catalyst Control Center and enable Crossfire. Update your drivers often and install the Catalyst Application Profiles.