Dual channel memory question

I will be using the Z68 chipset with 4 240-pin RAM slots compatible with a dual channel kit. I'm wondering...will I see the best performance if I get two separate, identical 2 x 4gb dual-channel kits...or if I get just one 4 x 4gb quad channel kit?

P.S. I've heard it's not good to occupy all avaliable RAM slots, however I must respectfully disagree. After personal experience and hours of research..I've seen no indication that a computer suffers performance, or overheating with all RAM slots occupied.
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