Yes I can. But I think if you put in a graphics card the pcie x1 card will be blocked.
fortunately this is my computer im modding just a bit before i spend 800$ on one i can really use and ill just take out the part for the other computer
If you also want to upgrade the hold motherboard include the card reader slots, this one will be fine too. It can upgrade your card readers and add 3 more USB 3.0 slots to your motherboard.
It also needs PCI-E x1 slot as the PCI-E expansion card needs.